Saturday, January 2, 2010

NEW FORM OF MALARIA

New form of malaria threatens Thai-Cambodia border

By MARGIE MASON and MARTHA MENDOZA - Associated Press Writers



PAILIN, Cambodia -- O'treng village doesn't look like the epicenter of anything.
Just off a muddy rutted-out road, it is nothing more than a handful of Khmer-style bamboo huts perched crookedly on stilts, tucked among a tangle of cornfields once littered with deadly land mines.
Yet this spot on the Thai-Cambodian border is home to a form of malaria that keeps rendering one powerful drug after another useless. This time, scientists have confirmed the first signs of resistance to the only affordable treatment left in the global medicine cabinet for malaria: Artemisinin.
If this drug stops working, there's no good replacement to combat a disease that kills 1 million annually. As a result, earlier this year international medical leaders declared resistant malaria here a health emergency.
"This is not business as usual. It's something really special and it needs a real concerted effort," said Dr. Nick White, a malaria expert at Mahidol University in Bangkok who has spent decades trying to eradicate the disease from Southeast Asia. "We know that children have been dying in Africa - millions of children have died over the past three decades - and a lot of those deaths have been attributed to drug resistance. And we know that the drug resistance came from the same place."
Malaria is just one of the leading killer infectious diseases battling back in a new and more deadly form, the AP found in a six-month look at the soaring rates of drug resistance worldwide. After decades of the overuse and misuse of antibiotics, diseases like malaria, tuberculosis and staph have started to mutate. The result: The drugs are slowly dying.
Already, The Associated Press found, resistance to malaria has spread faster and wider than previously documented. Dr. White said virtually every case of malaria he sees in western Cambodia is now resistant to drugs. And in the Pailin area, patients given artemisinin take twice as long as those elsewhere to be clear of the parasite - 84 hours instead of the typical 48, and sometimes even 96.
Mosquitoes spread this resistant malaria quickly from shack to shack, village to village - and eventually, country to country.
And so O'treng, with its 45 poor families, naked kids, skinny dogs and boiling pots of rice, finds itself at the epicenter of an increasingly desperate worldwide effort to stop a dangerous new version of an old disease.

Bundled in a threadbare batik sarong, 51-year-old Chhien Rern, one of O'treng's sick residents, sweats and shivers as a 103-degree fever rages against the malaria parasites in her bloodstream.
Three days ago Chhien Rern started feeling ill while looking for work in a neighboring district. So she did what most rural Cambodians do: She walked to a little shop and asked for malaria medicine. With no prescription, she was handed a packet of pills - she's unsure what they were.
"After I took the drugs, I felt better for a while," she says. "Then I got sick again."
The headaches, chills and fever, classic symptoms of malaria, worsened. Chhien Rern's daughter persuaded her to take a motorbike taxi past washed out bridges and flooded culverts to the nearest hospital in Pailin, a dirty border town about 10 miles from O'treng.............
READ MORE:http://www.thestate.com/sportswire/story/1087143.html


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